Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in ...
Role of PDEs in regulation of signal transduction. In the model of the second messenger concept originally put forth by Sutherland and Rall (14), first messengers—such as hormones, neurotransmitters, ...
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